Though Trump has not formally secured the 1,237 delegates he needs to win the nomination -- and likely won't until June -- there is no serious opposition left to block his path.
His victory amounts to a stunning takeover of the Republican Party by a candidate with no political experience. Along the way, he eviscerated the GOP's most accomplished presidential field in a generation and captured the Zeitgeist of a party in which grass roots voters harbor deep ill will toward establishment elites.
"It is a beautiful thing to watch, and a beautiful thing to behold," Trump said during a victory speech. "We are going to make America great again."
Cruz tried everything to pull off a last-ditch win in Indiana, including the unusual move of selecting Carly Fiorina as his running mate even though he wasn't the nominee. He also forged a pact with John Kasich that would allow him to focus on Indiana while the Ohio governor would devote his time to later states.